Faculty profile

Mohammed Uddin

Assistant Professor - Human Genetics

College of Medicine

mohammed.uddin@mbru.ac.ae

+971 4 383 8722

Professional Education

  • Bachelor of Science (Honors) – Memorial University of Newfoundland
  • Master of Science - Memorial University of Newfoundland
  • PhD in Human Genetics - Memorial University of Newfoundland

Mohammed Uddin, PhD, is a geneticist who obtained his bachelor, MSc., and PhD from Memorial University, Newfoundland, Canada. Mohammed has received the international Banting Fellowship 2014 by the Canadian Institutes for Health Research (CIHR) and was also awarded the Andrew Sass-Kortsak award by SickKids as the fellow of the year. He made significant contribution into the etiology of autism and neurodevelopmental disorder genetics. His current research interest primarily focuses on the applucation of CRISPR technology and single cell genomics to identify genetic etiology of neurodevelopmental disorders.

Academic AppointmentsTeachingResearch interestsMembershipsHonors and AwardsPublications

Academic Appointments

  • 2017 -  present Mohammed Bin Rashid University of Medicine and Health Sciences, College of Medicine
  • 2015 - 2017 - International Banting Fellow, The Hospital for Sick Children, Toronto, Canada
  • 2012 - 2017 - Fellow at The Hospital for Sick Children, Toronto, Canada

Teaching

  • Genetics and Molecular Biology – MEDC 1232
  • Mentoring Graduate, Intern Students.

Research interests

My research includes understanding the composition of the human genome for studies of genetic disease with a specific focus on autism spectrum disorder and other neurodevelopmental disorders. My recent work characterizes a set of DNA functional units (exons) that are critical for highly expressed in developmental human brain and are constrained for accumulating pathogenic mutations in general population. These ‘critical-exons’ are found to be highly associated with autism spectrum disorder and other neurodevelopmental disorders. Long-standing endeavors include the study of mutational mechanism for therapeutic purposes.

Membership of Professional Bodies / Associations

  • American Society of Human Genetics
  • Human Genome Variation Society
  • Autism Tissue Program
  • World Congress of Psychiatric Genetics

Honors and Awards

  • 2016  28th Andrew Sass-Kortsak Award, Best trainee of the year, The Hospital for Sick Children, Toronto, Ontario, Canada.
  • 2015  Best Paper of the Year Award, Genetics and Genome Biology (GGB), The Hospital for Sick Children, Toronto, Ontario, Canada.                      
  • 2015  Canadian Institutes of Health Research (CIHR) Postdoctoral Fellowship, Canada
  • 2015  Centre for Genetic Medicine Travel Award, The Hospital for Sick Children, Toronto, Canada
  • 2015  International Banting Postdoctoral Fellowship, Canadian Institutes of Health Research,140,000$
  • 2015  McLaughlin Centre Training Award, University of Toronto, Canada.
  • 2014  Centre for Genetic Medicine Travel Award, The Hospital for Sick Children.
  • 2014  McLaughlin Centre Training Award, University of Toronto, Canada.
  • 2011-12  Janeway Trainee Research Grant, Child Based Research Grant. Eastern Health, Health Science, St. John’s, Newfoundland.
  • 2012  Canadian Rheumatology Association (CRA) Basic Science Award, Canada.
  • 2011 Best Ph.D. Research Presentation Award, Discipline of Human Genetics, Faculty of Medicine, Memorial University of Newfoundland, Newfoundland, Canada.
  • 2011 Colman Graduate Student Award. Faculty of Medicine, Memorial University of Newfoundland, Newfoundland, Canada.
  • 2010  Canadian Rheumatology Association (CRA) Basic Science Award, Canada.
  • 2005  Department of Computer Science Silver Jubilee Course Achievement Award, Memorial University of Newfoundland, Canada.

Publications

  • 1. A high-resolution copy-number variation resource for clinical and population genetics. Genomic in Medicine

    View on PubMed
  • 2. Brain-expressed exons under purifying selection are enriched for de novo mutations in autism spectrum disorder. Nature Genetics

    View on PubMed
  • 3. Detection of clinically relevant genetic variants in autism spectrum disorder by whole-genome sequencing. American Journal of Human Genetics

    View on PubMed
  • 4. Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder. Nature Neuroscience

    View on PubMed
  • 5. Genome-wide characteristics of de novo mutations in autism.NPJ Genomic Medicine

    View on PubMed
  • 6. Indexing Effects of Copy Number Variation on Genes Involved in Developmental Delay. Scientific Reports

    View on PubMed
  • 7. Molecular Diagnostic Yield of Chromosomal Microarray Analysis and Whole-Exome Sequencing in Children With Autism Spectrum Disorder. JAMA

    View on PubMed
  • 8. Disruption of the ASTN2/TRIM32 locus at 9q33.1 is a risk factor in males for autism spectrum disorders, ADHD and other neurodevelopmental phenotypes. Human Molecular Genetics

    View on PubMed
  • 9. Whole-genome sequencing of quartet families with autism spectrum disorder. Nature Medicine

    View on PubMed
  • 10. Sonic hedgehog (Shh) signaling promotes tumorigenicity and stemness via activation of epithelial-to-mesenchymal transition (EMT) in bladder cancer. Molecular Carsiogenesis.

    View on PubMed
  • View all publications on PubMed

Contact Us

Building 14, Dubai Healthcare City
P.O Box 505055, Dubai UAE

Phone: 800 MBRU (6278)
Email: info@mbru.ac.ae

Copyright © 2017 Mohammed Bin Rashid University of Medicine and Health Sciences

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